Quote Originally Posted by Tom Alicoate
Does this mean that if DOF is a goal, and keeping a lens close to its sweetspot is a goal, than a APS-C sensor actually has some advantage here?

I'm sure Daniel will have a more authoratitative answer, but my guess is the reason for the percieved "sweet spot" is that diffraction has not yet set in in. If this is true, then the answer would be no.