Two weeks in the US

[Haydn1971]

Looking at taking a two week holiday in the US, I realise it's a huge place, but pondering where to start, without bouncing all over the place ! I'm into mountains, coastal and amazing roads, but also love iconic cityscapes such as London and Paris.... My wife and I have done the stuff like the Icefields Parkway, The Pyrenees and the Alps, I personally love the Scottish Highlands and Islands (North of Skye), but my wife less so... So, given we've just a couple of weeks, the reluctance to bounce to all parts of the US, where's a good starting area for a two week holiday with photo opportunities that importantly, isn't over run with tourists.