You are correct, it does depend on the lighting and the subject. As long as the museum is empty, and no one is walking around to come between your camera and the item you are photographing, you can do a longish exposure. I've found that the crowding in museums makes it hard to do, and having the option of a fast shutter speed helps.


50mm F/1.8 1/60 sec ISO 3200, 5D MK II.