I own both, ST-E2 and Pocketwizards (but I do not have either of the new models yet). I started out with just the ST-E2 but found that the size of the room being used caused malfunctions. I was taking a group shot in an auditorium and the room was so large that I could not get a bounce that would fire both of the flashes I was using! I then got 4 Pocketwizards to cover those situations.





I use the ST-E2 when I want to shoot ETTL and I use the PW's when I want to shoot manual. It's a little expensive to have both but I can cover all my bases this way.





If you were never going to need to use the ST-E2 in a large space (or outdoors) then it would be fine for you. I've seen good reviews on other wireless remotes other than PW's but have no first hand knowledge of them nor of the new PW models.