Business travel...laptop, too? I use a LowePro DSLR Video Fastpack 250AW. The bottom compartment holds my 1D X with RRS L-bracket, three 'standard' lenses (usually 11-24/4L, 24-70/2.8L II and TS-E 17/4L, one must be mounted), and I can fit my EOS M2 + M11-22 in there as well. Top compartment holds a change of clothes and a small toiletries bag. Laptop compartment holds my 17" MacBook Pro and a 9.7" iPad Pro (the latter in a neoprene sleeve). Requires a strong back, only complaint about the pack is that the hip belt is not padded. Has an all-weather cover tucked in, tripod mounts to the side.

Hope that helps...