I can walk around with my 500 f/4, and hand hold for short periods of time without straining my wrist and arm too much. I use a Black Rapid strap and it works fairly well. I'm sure that I would not be able to do that with the 600 f/4. When I was taking photos from a ship in Svalbard, that is the setup I used as you can see below. I used a dual Black Rapid system, and had a 70-200 lens on the second camera (only partially visible at the bottom of the frame).
The 500 f/4 is still a fairly hefty lens to have to hold up, so if you're not careful then you could end up causing some long-term damage to nerves in your wrist (or something similar to that) by trying to support it for longer than you should.






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