At a certain point the noise issue will bite you at too high a resolution and too low light level. True, you can always integrate the signal over several pixels but the net result of that is a higher noise floor vs. having one large pixel capturing the same number of photons. I'm certain that for bright light conditions it should be possible to reach ~100 MP given the sharpness of the best lenses and improvements to sensors that we know how to do. However, I fear for low-light conditions.