Almost sounds like a Ken Rockwell post, doesn't it?
Seriously, though, I realize that there are times when MLU is important (long lenses on tripods, night/low light situations, etc).
Good lighting, sturdy tripod/ballhead, remote switch or timer, then it shouldn't make much of a difference on the image sharpness, correct?
What would be the cut off point, in terms of benefit? A shutter speed that is the reciprocal of the len's focal length?