The classic trade off .... more (smaller) pixels which are more sensitive to proper sharpness technique and don't perform as well in low light but under the right conditions will excel at providing extreme detail, very large prints and more "crop-ability" versus less (larger) pixels which will perform much better in low light and will be a bit more tolerant of less than perfect technique and usually will image at a faster frame rate. It's all about the basic physics .... you have to choose the best tool (camera) for your purpose. Maybe have one of each