One very nice thing about LightRoom, The develop module was designed to allow a generally accepted workflow from top to bottom of the adjustment panel. In other words, start at the top of the adjustment panel and work your way down. I try and stick to this and it seems to work very well. Then, if you need to make specific adjustments, "edit in" Photoshop and make desired adjustments, then simply hit the save button and the image will be saved with edits back into the lightroom catologue. Agree with the others---sharpening and NR should be one of the last things you do.